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Trypanosomiasis, american
Pathology
  • Acute phase: after local invasion of histiocytes and draining lymph nodes, trypanosomes are disseminated via the blood stream. Destruction of host cells by multiplying amastigotes leads to inflammation, oedema and fever. Enlargement of liver and spleen.
  • Chronic phase: either asymptomatic or cardiac and CNS manifestations

 

 Sequelae of Trypanosoma cruzi infection

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