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Trypanosomiasis, african Pathology
- One week after the chancre appears, the infection reaches the regional lymph nodes, causing lymphadenitis. Puncture of these lymph nodes will reveal trypanosomes.
- In the late stage, there is body wasting, somnolence and signs showing involvement of the CNS (reversal of sleeping pattern)
- Disease due to T. brucei gambiense may run a protracted course of several years
- Disease due to T. brucei rhodesiense is lethal within weeks or a few months without treatment. CNS invasion and symptoms are seen within weeks.
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