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Trypanosomiasis, african
Pathology
  • One week after the chancre appears, the infection reaches the regional lymph nodes, causing lymphadenitis. Puncture of these lymph nodes will reveal trypanosomes.
  • In the late stage, there is body wasting, somnolence and signs showing involvement of the CNS (reversal of sleeping pattern)
  • Disease due to T. brucei gambiense may run a protracted course of several years
  • Disease due to T. brucei rhodesiense is lethal within weeks or a few months without treatment. CNS invasion and symptoms are seen within weeks.

 

Sequelae of Trypanosoma brucei gambiense/rhodesiense infection

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