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Toxoplasmosis
Pathology
  • Acute infection: sporozoites from oocysts or bradyzoites from ingested tissue cysts become tachyzoites which invade the intestinal mucosa. Via lymphatic vessels, they infect the regional lymph node and are then distributed via blood to many organs. Tachyzoites can invade all nucleated cells. Acute infection can be asymptomatic or is a febrile disease with a variety of symptoms. In most infected hosts, an effective immune response is built up.
  • Persisting chronic infection: bradyzoites persist in tissue cysts (e.g. in the brain, muscle) for life without causing disease. In AIDS patients or after immunosuppressive treatment, recrudescent infections may result: multiplying tachyzoites may produce multiple necrotic lesions in the brain or in other tissues. This results in all forms of systemic disease which may be fatal!

 

Sequelae of infection with Toxoplasma gondii

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