| Antibody detection by ELISA using excretory/secretory antigens from larval cultures is the standard diagnostic test. Detecting IgG4 antibodies leads to better specificity but with a considerable loss in sensitivity. Serological results cannot differentiate past from active infections. In treated patients, one might observe a decline in antibody titres within 6–12 month post-therapy which might indicate successful treatment. | - High sensitivity (75–90%) and good specificity (but not in poly-parasitised patients)
- No differentiation of past and active infection
- Commercially available ELISA test kits
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