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Paragonimiasis Diagnosis
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Paragonimiasis
Diagnosis

Diagnostic methods

Parasitological diagnosis
Ova can be found in sputum or faeces. Humans can be infected with several species (P. westermani, P. heterotremus, P. kellicotti, P. uterobilateralis and others).
WARNING: acid-fast staining for tuberculosis destroys the eggs and precludes diagnosis!

Molecular diagnosis
PCR-RFLP or multiplex PCR allows the species differentiation of metacercariae or adult worms

Antigen detection
No tests developed so far

Antibody detection
Home-made serological tests (mainly ELISAs using crude worm extracts or excretory/secretory antigens) have been developed which all have a problem with specificity. Tests with recombinant antigens have not yet been fully validated.

 

Diagnostic strategies

Besides parasitological examinations, no special diagnostic strategy can be recommended today!

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