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Diagnostic Methods
Diagnostic methodsPros and cons
Parasitological diagnosis 
As for other liver flukes, diagnosis is achieved by detecting eggs in faecal samples. Due to considerable variability in size, it is difficult to distinguish eggs of different Asian liver fluke species. 
Molecular diagnosis 
There have been first attempts to detect and differentiate DNA from Asian liver flukes (C. sinensis, O. viverrini and O. felineus) in faecal samples using specific primers
  • Methods not available in rural areas
Antigen detection 
No tests developed so far 
Antibody detection 
Serological tests using crude worm antigens have good sensitivity but low specificities (cross-reactions with other trematode infections).
A better specificity – with a considerable loss in sensitivity! – can be achieved using recombinant or purified antigens (e.g. cysteine proteinase or excretory/secretory antigens).