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Loiasis Pathology
- Migration of immature and adult worms in subcutaneous tissue is very often asymptomatic
- In sensitized patients, hyper-reactions against excretory/secretory products and microfilariae may lead to oedemas (calabar swellings)
- Live adult worms do not evoke inflammatory reactions in contrast to dying worms which elicit granulomatous reactions and fibrosis
- High blood eosinophilia is common
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