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Clonorchiasis Diagnosis 1
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Clonorchiasis Diagnosis 2
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Clonorchiasis
Diagnosis

Diagnostic methods

Parasitological diagnosis
Diagnosis is proven by finding the characteristic eggs in faeces or in duodenal fluid (by duodenal aspiration or with the “string test”).
Multiple samples and concentration methods improve sensitivity in light infections!

Molecular diagnosis
First attempts to detect and differentiate DNA from Asian liver flukes (C. sinensis, O. viverrini and O. felineus) in faecal samples using specific primers

Antigen detection
No tests developed so far

Antibody detection
Serological tests using crude worm antigens have low specificities (cross-reactivity with other trematode infections).
A better specificity can be reached using recombinant or purified antigens (e.g. cysteine proteinase or excretory/secretory antigens). However, there is a loss in sensitivity.

 

Diagnostic strategies

  1. Screening populations to assess prevalence
    Perform a cross-sectional study analysing fixed stool specimens with a concentration method (preferably after sedimentation).
    As an alternative screening method, serology could be used (if multiple trematode species are not prevalent!)
     
  2. Detecting clonorchiasis in exposed individuals
    Examine one or multiple fresh stool specimens for ova after concentration
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