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Diagnostic Strategies
  1. To diagnose a suspicious case of invasive amoebiasis
    For screening, serology is the first choice. In early infection, serology might be negative due to the retarded detection of circulating antibodies. Amoebae can also be detected in abscess aspirates by microscopy or PCR. Stool examinations are often negative in invasive amoebiasis.
  2. To detect asymptomatic carriers of E. histolytica
    Screen stool samples with an antigen detection assay or with PCR. Microscopy and serology have no diagnostic value for carriers!